活性確認済みの変異体キナーゼ
ProQinase offers one of the largest collections of recombinant protein kinase mutants. All mutants have passed ProQinase’s quality control including activity testing and IC50 determination of reference inhibitors. Most of the mutant kinases are available as recombinant protein in amounts starting with 10 μg up to mg scale, all are available for biochemical screening services. In addition the corresponding wild type kinases are available (except RAF1 wt and MKK6 wt).
Lot specific datasheets for all recombinant kinases and detailed Info Sheets for kinase mutant families are available, please refer to www.proqinase.com
ABL1
| ABL1 G250E | ABL1 T315T |
| ABL1 Q252H | ABL1 F317I |
| ABL1 Y253F | ABL1 M351T |
| ABL1 E255K |
ABL1 H396P |
ALK
| ALK C1156Y | ALK L1196M |
| ALK F1174L | ALK R1275Q |
| ALK F1174S |
B-RAF
| B-RAF V600E |
DDR2
| DDR2 N456S | DDR2 T654M |
EGF-R
| EGF-R d746-750 | EGF-R G719S |
| EGF-R d747-749/A750P | EGF-R L858R |
| EGF-R d747-752/P753S | EGF-R L861Q |
| EGF-R d752-759 | EGF-R T790M |
| EGF-R G719C | EGF-R T790M/L858R |
FGF-R1
| FGF-R1 V561M |
FGF-R3
| FGF-R3 K650E | FGF-R3 G697C |
| FGF-R3 K650M |
FLT3
| FTL3 ITD | FLT3 D835Y |
KIT
| KIT V654A | KIT T670I |
| KIT V559D | KIT D816H |
| KIT V559D/V654A | KIT D816V |
| KIT V559D/V670I | KIT A829P |
| KIT V560G |
LRRK2
| LRRK2 R1441C1 | LRRK2 I2020T1 |
| LRRK2 G2019S1 |
MEK1
| MEK1 S218E/S222E2,3 |
MET
| MET F1200I | MET Y1230D |
| MET D1228H | MET Y1230H |
| MET D1228N | MET Y1235D |
| MET Y1230A | MET M1250T |
| MET Y1230C |
MKK6
| MKK6 S207D/T211D2 |
PDGFR-alpha
| PDGF-R alpha V561D | PDGF-R alpha D842V |
| PDGF-R alpha T674I |
RAF1
| RAF1 Y340D/Y341D (GST-HIS-tag)2,3 | RAF1 Y340D/Y341D (untagged)2 |
RET
| RET G691S | RET V804M |
| RET R749T | RET R813Q |
| RET E762Q | RET S891A |
| RET Y791F | RET M918T |
| RET V804L |
TIE2
| TIE2 R849W | TIE2 Y1108F |
| TIE2 Y897S |
1 Only available for screening services
2 Artificial, constitutive active mutant
3 Not available for screening services